Sirelines

Sirelines are the figurative bloodlines of vampires or hybrids and the chain of those by whom they have been sired. If the originator of a bloodline is permanently killed with a White Oak Stake, or by other means, everyone in their bloodline dies within a few hours. It was a powerful and sophisticated link added to the immortality spell by Esther as a method of further protecting her children.

Rebekah and Kol are the two living Originals with and without a sireline, respectively. As such, all remaining vampires are either from Klaus' unlinked sireline or from Rebekah's sireline, as it remains unknown if Kol or Elijah has turned any other vampires following their resurrections. There is yet to be any vampires sired from an Enhanced or an Upgraded Original vampire.

Original Vampire Bloodlines
Mikael †

Finn Mikaelson †
 * Sage †
 * Troy †
 * Many Unknown Vampires †

Elijah Mikaelson
 * Tristan de Martel †
 * Aya Al-Rashid †
 * Mohinder †
 * Shen Min †
 * The Strix †
 * Many Unknown Vampires †
 * Rowan Obi †
 * Emil Blankenship †
 * Lawrence Howard †
 * Cadence Flynn †
 * Takahashi Fukuda †
 * Arthur Bailey †
 * Claire Burnett †
 * Robert Craig †
 * Isaac Pacheco †
 * Holt †
 * Laurent †

Kol Mikaelson
 * Many Unknown Vampires †

Rebekah Mikaelson
 * Aurora de Martel (Slumbering)
 * Unnamed Vampires †
 * Camille O'Connell †
 * Lenore †
 * Many Unknown Vampires

Original Hybrid Bloodline (Broken)
Niklaus Mikaelson
 * -|Vampires=
 * Lucien Castle †
 * Gregory
 * Anton †
 * Mary Porter †
 * Rose-Marie †
 * Trevor †
 * Katerina Petrova (Formerly)
 * Pearl †
 * Harper †
 * Annabelle †
 * Logan Fell †
 * Ben McKittrick †
 * Tomb Vampires †
 * Noah †
 * Henry Wattles †
 * Stefan Salvatore (Formerly)
 * Patient †
 * Unnamed Frat Boy (Sired while possessed by Ambrose)
 * Violet Fell †
 * Virginia Salvatore †
 * Liliya Petrova † (Formerly)
 * Damon Salvatore (Formerly)
 * Charlotte
 * Isobel Flemming †
 * Kimberly Donovan †
 * Caroline Forbes
 * Jesse †
 * Colin Phelps †
 * Unnamed College Girl (Unknown Status)
 * Bill Forbes †
 * Abby Bennett Wilson
 * Patricia Gilbert (Formerly)
 * Gaspar Cortez †
 * Alistair Duquesne †
 * Marcel Gerard (Formerly)
 * Thierry Vanchure †
 * Max †
 * Tomas †
 * Felicia †
 * Otto †
 * Diego †
 * Joe Dalton †
 * Soldiers of The Brotherhood of the Damned †
 * Marcel's Army †
 * Joshua Rosza †
 * Gia †
 * Derek (Unknown Status)
 * Pizza Delivery Girl †
 * People from the bar †
 * Tina McGreevy †
 * Kieran O'Connell †
 * Many Unknown Vampires
 * -|Hybrids=
 * Ray Sutton †
 * Paige †
 * Tyler Lockwood † (Formerly)
 * Sloan † (Formerly)
 * Mindy †
 * Tony †
 * Daniel Warren †
 * Nate †
 * Dean †
 * Chris †
 * Kimberley †
 * Adrian †
 * 10 Hybrids †

Enhanced Original Vampire Bloodline
Alaric Saltzman (Formerly)

Upgraded Original Vampire Bloodlines
Lucien Castle (Formerly)

Marcel Gerard

Tribrid Bloodlines
Hope Mikaelson
 * -|Hybrids=
 * Dwayne †
 * Hayley Marshall-Kenner † (Formerly; bound with the Hybrid Curse)
 * Holly Labonair
 * Craig Labonair
 * Calvin Labonair
 * Victoria Labonair
 * Cyrus Labonair
 * Louis Labonair
 * Rosalie Gilbert-Donovan
 * Henry Benoit †
 * Many Unknown Hybrids

Miranda Mikaelson
 * -|Hybrids=
 * Elena Gilbert
 * Juliette Gilbert-Donovan

Rayna Mikaelson
 * -|Hybrids=
 * Katerina Petrova

Grayson Mikaelson

Unknown Bloodlines

 * Lexi Branson †
 * Lee (Unknown Status)
 * Frederick †
 * Bethanne †
 * Slater †
 * Cody Webber †
 * Nadia Petrova (Not part of Mikael's, Finn's or Kol's bloodlines)
 * Joey † (Not part of Mikael's, Finn's or Kol's bloodlines)
 * Will † (Not part of Mikael's, Finn's or Kol's bloodlines)
 * Unnamed nurse (Not part of Mikael's, Finn's or Kol's bloodlines)
 * Lillian Salvatore †
 * Malcolm †
 * Valerie Tulle
 * Nora Hildegard †
 * Mary Louise]] †
 * Beau †
 * Oscar †
 * Lorenzo St. John †
 * Many humans † (Turning into vampires to feed Damon)
 * Farmer John †
 * Ivy † (Formerly)
 * Tripp Cooke † (Formerly)
 * Malachai Parker †
 * Julian † (Not part of Mikael's, Finn's or Kol's bloodlines)
 * Raphael
 * Dirty Robin
 * Seth †
 * Xi Nguyen
 * Ellis †
 * Kyle †
 * Sampson †
 * Krystal †
 * Shawn †
 * Many Unknown Others
 * Spirit possessing Oscar †
 * Florence †
 * Sofya Voronova (Not part of Mikael's, Finn's, Elijah's or Kol's bloodlines)
 * Ambrose †
 * Rayna's Unnamed Lover †
 * Lewis † (Not part of Mikael's, Finn's or Kol's bloodlines)
 * Desmond †
 * Wyatt †
 * Bubba †
 * Ashlynn †
 * Meg †
 * Geoff †
 * Lane †
 * Michael †
 * Ann †
 * Cordis †
 * Ben †
 * Lee †
 * Jonathan †
 * Juan †
 * Carlos †
 * Margaret †
 * Many other phoenix stone vampires †


 * Poppy † (Not part of Mikael's, Finn's, Elijah's or Kol's bloodlines)
 * Greta Sienna † (Not part of Mikael's, Finn's, Elijah's or Kol's bloodlines)
 * Antoinette Sienna
 * Roman Sienna
 * August Müller † (Unknown bloodline)
 * Emmett † (Not part of Mikael's, Finn's, Elijah's or Kol's bloodlines)
 * Milton Greasley (Not part of Mikael's, Finn's, Elijah's or Kol's bloodlines)
 * Kaleb (Not part of Mikael's, Finn's, Elijah's or Kol's bloodlines)
 * Oliver (Not part of Mikael's, Finn's, Elijah's or Kol's bloodlines)
 * Sebastian (Not part of Mikael's, Finn's, Elijah's or Kol's bloodlines)